buprenorphine transdermal and diazepam both enhance sedation. Stay clear of or Use Alternate Drug. Limit use to patients for whom substitute treatment choices are insufficient
fluvoxamine will improve the degree or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Watch Carefully (two)diazepam will increase the degree or outcome of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
drospirenone will improve the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.
levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will boost the stage or result of diazepam by lowering metabolism.
crizotinib improves amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Dose reduction may very well be needed for coadministered medicines which might be predominantly metabolized by CYP3A.
Reserve concomitant prescribing of those medication in clients for whom other therapy options are inadequate. Restrict dosages and durations towards the least demanded. Keep an eye on intently for indications of respiratory despair and sedation.
diazepam will increase the level or impact of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Coadministration of moderate CYP3A4 inhibitors with midazolam intranasal may perhaps result in larger midazolam systemic publicity, which more info can prolong sedation.
Concomitant utilization of benzodiazepines, which include diazepam, and opioids may possibly lead to profound sedation, respiratory despair, coma, and Loss of life; reserve concomitant prescribing of benzodiazepines and opioids to be used in clients for whom substitute procedure possibilities are insufficient; cut down opiate dose one-3rd when diazepam is extra
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Reserve concomitant prescribing of those drugs in clients for whom other therapy solutions are inadequate. Limit dosages and durations towards the minimum amount necessary. Observe closely for indications of respiratory depression and sedation.
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phenobarbital will minimize the extent or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
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